Matrix metalloproteinase-9gene polymorphisms in nasal polyposis
نویسندگان
چکیده
منابع مشابه
Matrix metalloproteinase-2 gene polymorphisms in nasal polyps.
OBJECTIVE To systematically investigate the role of matrix metalloproteinase-2 (MMP2) tagging single nucleotide polymorphisms (SNPs) and promoter functional polymorphism in the development of nasal polyps in a Chinese population in Taiwan. DESIGN We conducted a case-control study in 136 cases of chronic rhinosinusitis with bilateral nasal polyps and 136 controls. Seventeen SNPs were selected,...
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OBJECTIVES/HYPOTHESIS Although many proinflammatory cytokines have been identified in nasal polyp tissue, the initial trigger that causes this inflammation characterized by edema, lymphocytosis, and eosinophilia, is still unknown. The purpose of the present study is to identify the presence of genetic polymorphisms in proinflammatory, anti-inflammatory, and chemokine genes that might contribute...
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OBJECTIVE To investigate the association between nasal polyposis (NP) and single nucleotide polymorphisms of the proinflammatory cytokines IL (interleukin) 1alpha (the IL1A gene), IL-1beta (the IL1B gene), and tumor necrosis factor alpha (the TNFA gene). DESIGN Prospective case-control trial. SETTING Tertiary referral center. PATIENTS Eighty-two patients with NP and 106 healthy volunteers...
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Matrix metalloproteinases (MMP) contribute to tumor microenvironment and are associated with bladder cancer. A study examining the association between MMP polymorphisms and bladder cancer risk has never been published. We analyzed the association of 11 single nucleotide polymorphisms (SNPs) and one microsatellite polymorphism in MMP genes MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, and MMP-12 with bladd...
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Since oral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity, several researches have been performed to study the role of important enzymes in this disease. Among them, the matrix metalloproteinases (MMPs) are highlighted, due to the fact that they are proteinases responsible to degrade many extra-cellular matrix components, making possible the invasion of...
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ژورنال
عنوان ژورنال: BMC Medical Genetics
سال: 2010
ISSN: 1471-2350
DOI: 10.1186/1471-2350-11-85